Smart DNA hydrogels with uncommon phase diagrams.
Bomboi F., Romano F., Leo M., Fernandez-Castanon J., Cerbino R., Bellini T., Bordi F., Filetici P., Sciortino F.
Hybridizing in a well-characterized and programmable fashion, DNA has nowadays become a keystone in the development of novel materials, designely self-assembling in a variety of nanostructures which act as functional building blocks. Along this line, we have recently created an innovative biomaterial, an unconventional DNA hydrogel, having the unprecedent peculiarity of melting both upon heating and upon cooling and displaying an uncommon re-entrant phase diagram. We will thus present this purposely designed gel and examine how to produce biocompatible and reversible materials with tailor-made properties and programmable temperature behaviour by enciphering in smartly chosen DNA sequences the physics of the collective thermal response.