Relazione su invito
Human brain project and multimodal optical imaging of whole brain.
In the beginning, a short introduction will be devoted to describing the HBP and the opportunities to reach the HBP community. After that, I will describe what we are doing in the frame of HBP. In particular, we are interested in the correlations between morphology of brain connections and functionality, which is one of the major issues in neuroscience in the understanding of many pathologies and mechanisms of behavior and computation. Elucidating the neural pathways that underlie brain function is also one of the greatest challenges in neuroscience. Nowadays, there are several imaging techniques offering a complementary approach to visualizing intact neural networks. Each of these offers a different strategy and furnishes complementary information on the role of neural components. We will describe different approaches enabling to move from single neuron details to whole brain imaging both from the functional and the morphological point of view. Some examples of correlative microscopies, combining linear and nonlinear techniques will be described. Particular attention will be devoted to neural plasticity after damage as neurobiological application.