Interfacing primary cortical neurons with PMCS TiO$_{2}$ films to design bio-hybrid memristive device mimicking neuromorphic functionalities.

Jimenez-Garduño A.M., Roncador A., Pasquardini L., Giusti G., Cornella N., Lunelli L., Potrich C., Bartali R., Aversa L., Verucchi R., Dalla Serra M., Caponi S., Iannotta S., Pederzolli C., Macchi P., Musio C.
  Martedì 12/09   09:00 - 13:00   Aula A209   V - Biofisica e fisica medica
In the framework of the project MaDEleNA, funded by PAT Trento, aimed to interface biological systems with memristive surfaces to study hybrid neuromorphic functionalities, we report a comprehensive study of the biocompatibility of titanium dioxide films (TiO$_2$) prepared by Pulsed Microplasma Cluster Source (PMCS). All the films showed consistent neurocompatibility that favors the adhesion and growth of murine cortical neurons. Moreover, the bioelectrical activity of the neuronal culture grown on the $TiO_{2}$ film has been successfully measured by patch-clamp electrophysiology. Our results satisfy the goal to design memristive bio-hybrids mimicking neuronal plasticity for applications in cognitive and rehabilitation neurosciences.