Soft optoelectronic interfaces to the brain.
Advanced optoelectronic systems capable of intimate integration into the depth and/or onto the surface of the brain have the potential to accelerate progress in neuroscience research and to establish new therapies in clinical medicine. Specifically, capabilities for injecting electronics, light sources, photodetectors, multiplexed sensors, programmable microfluidic networks and other components into precise locations of the deep brain and for softly laminating them onto targeted regions of the cortical surface will open up unique and important opportunities in stimulation, inhibition and real-time monitoring of neural circuits. In this talk, we will describe foundational concepts in physics and materials science for these types of technologies, in 1D, 2D and 3D architectures. Examples in system level demonstrations include experiments on freely moving animals with cellular-scale, injectable optofluidic neural probes for optogenetics research and with bioresorbable, implantable intracranial sensors for treatment of traumatic brain injury.