Functionalization of SiC/SiO$_{x}$ core/shell nanowires: Oxidative stress-generating nanomaterials for anti-cancer therapy.

Timpel M., Tatti R., Loffi C., Pasquardini L., Nardi M.V., Rossi F., Bigi F., Verucchi R., Salviati G.
  Mercoledì 13/09   09:00 - 13:00   Aula A222   V - Biofisica e fisica medica
Recent research in nanomedicine has shown that functionalization of nanomaterials by attaching photosensitizers ($e.g.$, porphyrins) confers unique oxidative stress-generating properties under near-infrared (NIR) or X-ray exposure and induces tumor cell death without the need for chemotherapy. One highly appealing nanomaterial that can be used as X-ray scintillator are $SiC/SiO_{x}$ core/shell nanowires, whose X-ray excited optical luminescence matches well the porphyrin's absorption. This energy matching allows for a NW-mediated energy transfer to the porphyrin, rendering it suitable for X-ray excited anti-cancer therapy. In the present communication, an overview about our recent activities in this field of research will be given.