Magnetosomes extracted from Magnetospirillum gryphiswaldense as theranostic agents in experimental model of glioblastoma.
Mannucci S., Tambalo S., Orlando T., Fantechi E., Ghin L., Bassi R., Lascialfari A., Sangregorio C., Sbarbati A., Marzola P.
Magnetotactic bacteria, discovered by Salvatore Bellini in 1963, synthesize iron oxide nanoparticles covered by biological material that are called magnetosomes. Magnetotactic bacteria use the magnetosomes as a compass to navigate in the direction of the earth's magnetic field. Magnetosomes have sizes in the range 45--55 nm and are organized in chains. Magnetosomes are currently considered as contrast agents for MRI and as heating mediators for magnetic fluid hyperthermia. We have investigated the magnetic and hyperthermia properties of magnetosomes extracted from $Magnetospirillum gryphiswaldense$. Studies have been performed $in vitro$ and $in vivo$ in an experimental model of human glioma.